NS 4900 - [Manipulating the Mouse Genome]

(crosslisted)
(also BIOMG 4900)

Fall. 1 credit. S-U or letter grade option.

Prerequisites: BIOMG 2800, BIOMG 2810, BIOMG 3300, BIOMG 3320 or BIOMG 3330, or NS 3200. Offered alternate years. Next offered 2012-2013. Meets during first half of semester and provides background information for VTBMS 7010/TOX 7010 Mouse Pathology and Transgenesis, which meets during second half. Students interested in both must register for them separately.

P. Soloway.

Functional genomic analysis has benefited enormously from experimental manipulation of the genomes of many organisms. The mouse has been the model of choice for such studies in mammals. Explores the tools available for experimental manipulation of the mouse genome, including transgenesis, gene targeting, gene trapping, chemical mutagenesis, use of induced pluripotent stem cells, and cloning by nuclear transplant. Also discussed are use of recombinant inbred mice and genome-wide association studies for complex trait analysis. Readings from the scientific literature focus on seminal applications of these methods.