VTBMS 6100 - Genomes as Chromosomes

Fall. (Offered alternate years) 1 credit. Letter grades only.

Prerequisite: upper-level undergraduates and graduate students; others by permission of instructor or BIOGD 2810 and BIOBM 3320.

P. Cohen.

The eukaryotic genome is partitioned into discrete structural units, the chromosomes. This course examines how chromosome organization is related to chromatin structure, gene expression, DNA replication, repair, and stability. Special emphasis is placed on how the linear arrangement of sequence features along the chromosome, such as genes and regulatory modules, relate to the functional organization of the genome in the nucleus. Experimental and computational approaches used to address chromosome structure and function are studied.