Toxicology (TOX)

TOX 4370 - Molecular Basis of Aging Biology (3 Credits)
Crosslisted with BIOMG 4370
This course primarily focuses on the genetic, molecular and cellular basis of aging biology, with an emphasis on how experimental insights obtained from animal and cell models inform our understanding of the aging process. We will also learn about the evolutionary aspect of aging based on comparative studies. Subject matter will include not only what we know about the molecular basis of aging biology but also how we learned it. The course is designed to introduce the conserved pathways and processes that influence aging biology.
Prerequisites: BIOMG 2800 or BIOMG 3320 or equivalent.
Learning Outcomes:
  • Describe at least three principles that are known to have a major impact on the aging process.
  • Compare and contrast at least five hallmarks of aging at molecular, cellular, and organismal levels, describe how these hallmarks interconnect to drive age-related decline.
  • Explain the major strengths and weaknesses of the common experimental systems used to study aging biology.
  • Identify at least three conserved pathways that influence aging based on current research.
  • Evaluate primary literature on a chosen topic relates to aging biology.
Schedule of Classes
TOX 7010 - Mouse and Stem Cell Pathology (1 Credit)
Crosslisted with VTBMS 7010
Introduction to principles and methods of pathology. Pathology role in stem cell research, regenerative medicine and cancer biology. Systematic evaluation of mouse models, with a particular attention to such topics as experimental design, model validation, identification of novel phenotypes, histotechnology and mouse necropsy.
Enrollment Information: Recommended prerequisites: BIOAP 4130.
Last Four Terms Offered: Fall 2025, Fall 2024, Fall 2023, Fall 2021
Learning Outcomes:
  • Understand principles and methods of pathology as discipline.
  • Experience in planning of animal experiments, collecting and processing of biological materials.
  • Become familiar with pathology terminology.
  • Learn about the role of stem cell pathology in stem cell research and regenerative medicine.
Schedule of Classes