VETMM 7030 - Receptor-Ligand Interactions

Fall. 1 credit.

G. A. Weiland, R. E. Oswald.

The course covers both the practical and theoretical tools for the study of ligand-receptor interactions, emphasizing the quantitative and physical chemical aspects of receptor theory. Topics discussed are basic methods of radioligand binding assays, including separation and measurement of bound and free ligand; characterization of receptor function; analysis of receptor structure; allosteric modulation; rational drug design; thermodynamic basis of binding; methods of analyzing equilibrium binding; equilibrium binding for complex mechanisms; and kinetics of simple and complex binding mechanisms.