BIOAP 4750 - [Mechanisms Underlying Mammalian Developmental Defects]

(crosslisted)
(also BIOMS 4750, NS 4750) (PBS)

Spring. 3 credits.

Prerequisite: BIOMG 3300, BIOMG 3310-BIOMG 3320, or BIOMG 3330 (may be taken concurrently). Next offered 2015-2016. (Offered even years)

D. Noden, P. Stover.

Focuses on the causes of developmental defects and how genetic changes or teratogenic insults disrupt developmental regulatory and metabolic pathways.

Outcome 1: Characterize developmental defects at the gross, cellular, biochemical, and genetic levels.

Outcome 2: Assess the relative contributions of genetic variations, epigenetic events, and environmental factors in the etiology of developmental defects.

Outcome 3: Evaluate the applicability of animal models to our understanding of human developmental defects.

Outcome 4: Identify key processes and fundamental principles of animal development, and relate disruptions in these to abnormal outcomes.

Outcome 5: Recognize the necessity of integrating information, often incomplete, at multiple levels of organization into a coherent and plausible explanation of a developmental defect.