CHEM 7880 - Macromolecular Crystallography

Spring. 3 credits. Letter grades only.

Prerequisite: Introductory Calculus and Introductory Physics.

S. E. Ealick.

Lectures cover the fundamentals of X-ray crystallography with a practical emphasis on methods for determining the three-dimensional structures of macromolecules. Topics include crystallization, data collection, phasing methods, model building, refinement, structure validation, and structure interpretation. The final project will include a complete structural analysis of a protein.