NS 4410 - Nutrition and Disease

Fall. 4 credits. Student option grading.

Prerequisite: Biochemistry (can be taken concurrently if student is a Senior).

M. Caudill.

Principles of nutrition, biochemistry, physiology, genetics, pathology, and pharmacology are combined to understand disease risk, prevention, progression, and management. Lecture offers opportunities for the class to engage in the discussion of original research articles on topics of high current interest in the area of nutrition and health. Topics include nutritional genomics, obesity, cardiovascular disease, diabetes mellitus, renal, neurological, and gastrointestinal disorders.

Outcome 1: Show a working knowledge of the pathophysiology, and altered metabolism, that occurs in various disease states.

Outcome 2: Identify molecular targets for disease prevention and/or treatment (eg, angiotensin receptors, AMP kinase, ATP‐binding cassette transporter, Niemann‐Pick C1 Like 1, caspases, COX 2 pathway, HMG CoA reductase, vascular endothelia growth factor, glucagon like peptide 1, p53, PI‐3‐Kinase, Ras oncogene) and provide the rationale for the selection.

Outcome 3: Recognize and define key terms that are integral to understanding disease pathology, risk, and progression (eg, glucose sensing, non‐esterified free fatty acids, beta cell dysfunction, reverse cholesterol transport, insulin resistance, angiogenesis, epigenetic modifications, glomerular filtration rate, tumor suppressor gene, oncogene, microalbuminuria, advanced glycation end products, nicotinic acid receptors).

Outcome 4: Know and understand the rationale for nutritional strategies aimed at disease prevention and/or treatment (eg, limiting saturated fatty acid intake for lowering of low density lipoproteins; Adult Treatment Panel (ATP) guidelines).