|
|
Oct 11, 2024
|
|
BIOMG 4380 - RNA in Biology and Medicine (BIO-AS, PBS-AS) Fall. 3 credits. Student option grading.
Prerequisite: BIOMG 3300 , or BIOMG 3350 or BIOMG 3310 /BIOMG 3320 or permission of instructor. Co-meets with BIOMG 6380 .
A. Ke.
It is hypothesized that RNA may have been the earliest life form on earth. Nowadays RNA plays three vital roles in biology. It serves as an information carrier to guide biological processes; it adopts sophisticated 3D structures to promote recognition and catalysis; and it promotes cellular compartmentalization. Each of these properties has been exploited for therapeutics and medicine. This course explores the idea of a prehistorical “RNA World”, dives deep into interesting topics in the RNA biology, and explains their connection to modern medicine. Representative topics include the mechanisms of CRISPR-Cas and RNA interference and their
wide-spread applications in research and medicine, ribosome as an antibiotic target, perturbing splicing to cure genetic diseases, connection between telomerase and cancer/aging, etc. Classical experiments as well as up-to-date research are covered in this class. A portion of each class is devoted to student presentations and discussion. After completing this class, students should:
Outcome 1: Understand the chemical structure of RNA.
Outcome 2: Understand the structure motifs in RNA.
Outcome 3: Have a good understanding of the experimental and computational methods in RNA biology research.
Outcome 4: Understand the catalytic strategies in ribozymes.
Outcome 5: Understand the ligand recognition mechanism in riboswitches.
Outcome 6: Understand the role of RNA in important RNA-protein complexes.
Outcome 7: Understand the important topics in translation.
Outcome 8: Understand the RNA splicing/processing/editing process.
Outcome 9: Understand the mechanism of RNA interference in both eukaryotes and prokaryotes.
Add to Favorites (opens a new window)
|
|
|