NS 6080 - Epigenetics

(crosslisted)
(also BIOMG 6080)

Fall. 3 credits. Letter grades only.

Prerequisites: BIOMG 2810 and BIOMG 3300, or BIOMG 3320, or BIOMG 3330 or NS 3200.

P. Soloway.

Epigenetic effects refer to reversible alterations in chromatin structure that can stably and heritably influence gene expression. Changes include covalent modifications to DNA itself or to proteins bound to DNA as well as noncovalent remodeling of chromatin. Course examines selected epigenetic phenomena described in several eukaryotes, mechanisms regulating these effects, and their phenotypic consequences when normal regulation is lost. Reading materials are from current literature, and participation in class discussion is required.